Korean J Med > Volume 71(1); 2006 > Article
The Korean Journal of Medicine 2006;71(1):299-299.
Periprocedural Myonecrosis is associated with Adverse Cardiac Events after Drug-Eluting Stents Implantation
, , , , , , ,
국립의료원 내과
Periprocedural Myonecrosis is associated with Adverse Cardiac Events after Drug-Eluting Stents Implantation
Jae-Sik Jang, Myeong-Ki Hong, Duk-Woo Park, Young-Hak Kim, Cheol Whan Lee, Jae-Joong Kim, Seong-Wook Park, Seung-Jung Park
.
Abstract
Background : High level of creatine kinase myocardial band isoenzyme (CK-MB) elevation has been associated with late mortality after coronary intervention. We sought to evaluate the impact of periprocedural myonecrosis on clinical events in patients undergoing drug-eluting stents (DESs) implantation. Methods : A total of 1,807 consecutive patients (2,550 lesions) with successful DESs implantation were followed for mean duration of 13¡¾7 months. Patients with acute myocardial infarction were excluded. Based on the CK-MB levels after stenting, patients were classified into three groups: group I: normal CK-MB (n = 1,429, 79.1%), group II: 1 to 5 times normal CK-MB (n = 263, 14.6%), and group III: > 5 times normal CK-MB (n = 115, 6.4%). Major adverse cardiac events (MACE) were defined as death, myocardial infarction, and target lesion revascularization. Results : There were no significant differences in baseline clinical characteristics between the three groups. Patients with elevated CK-MB levels showed longer stent length, more number of stents per lesion, and smaller postintervention minimal luminal diameter. With increasing levels of periprocedural CK-MB, there was an increased incidence of MACE (4.7% in group I vs. 6.5% in group II vs. 11.3% in group III, p = 0.002) and death (0.6% in group I vs. 1.5% in group II vs. 3.5% in group III, p = 0.012). By multivariate analysis, periprocedural peak CK-MB level was independent predictor of MACE (HR 1.01, 95% CI 1.00 to 1.02; p = 0.041) and death (HR 1.02, 95% CI 1.00 to 1.04; p = 0.049) in addition to left ventricular ejection fraction, cutting angioplasty, and number of stents per lesion. Conclusions : Periprocedural myonecrosis was significantly associated with subsequent adverse clinical events after DESs implantation.


TOOLS
METRICS Graph View
  • 1,041 View
  • 0 Download

Editorial Office
101-2501, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-2271-6791    Fax: +82-2-790-0993    E-mail: kaim@kams.or.kr                

Copyright © 2024 by The Korean Association of Internal Medicine.

Developed in M2PI

Close layer
prev next