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The Korean Journal of Medicine 2006;71(1): 274-274.
Effect of Triple antiplatelet therapy with Low-dose cilostazol after DES Implantation
Effect of Triple antiplatelet therapy with Low-dose cilostazol after DES Implantation
1Department of Internal Medicine, Hanyang University College of Medicine, Seoul; 2Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Korea
Background : In the CREST trial, there was a significantly lower binary restenosis rate in the cilostazol-treated patients compared with the placebo-treated patients after bare-metal stent implantation. But it is uncertain that this result will be supported after drug-eluting stent(DES) implantation especially with long-term low-dose cilostazol. So, we performed a prospective randomized study to evaluate the effectiveness of long-term triple therapy with low-dose cilostazol after DES implantation. Methods : From June 2004 to January 2006, we assigned 109 patients(132 lesions) who had successful coronary DES implantation to receive aspirin and clopidogrel(Group I, n=53) or aspirin, clopidogrel and low-dose cilostazol(50mg BID) (Group II, n=56) for 6 months. The primary end point was in-segment restenosis at follow-up angiogram. The secondary end point were late loss, major adverse cardiac event, stent thrombosis. Results : The baseline clinical and angiographic characteristics were similar between two groups. Angiographic follow-up was completed in 74% of patients and there were no difference in the in-segment restenosis rate and there were also no significant differences in the secondary end points(Table 1). The target vessel revascularization rate was 3.6%. there was one case of non-cardiac origin death in group II. Conclusions : In our study there was no addititive effect of triple therapy with low-dose cilostazol in DES era.
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