Change of serum ghrelin concentration according to severity of hepatosteatosis

Yoo, Tae Woo; Cho, Yong Kyun; Kang, Mun Su; Oh, Se Yong; Park, Jung Ho; Kim, Hong Joo; Park, Dong Il; Sohn, Chong Il; Jeon, Woo Kyu; Kim, Byung Ik; Jung, Chan Hee; Rhee, Eun Jung; Lee, Won Young; Oh, Ki Won; Kim, Sun Woo; Yun, Eun Joo; Oh, Eun Sook

Korean J Med > Volume 71(1); 2006 > Article

Original Article

The Korean Journal of Medicine 2006;71(1):45-51.

Change of serum ghrelin concentration according to severity of hepatosteatosis

Tae Woo Yoo, Yong Kyun Cho, Mun Su Kang, Se Yong Oh, Jung Ho Park, Hong Joo Kim, Dong Il Park, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Chan Hee Jung, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sun Woo Kim, Eun Joo Yun, Eun Sook Oh

한림의대 한강성심병원 내과

비알코올성 지방간의 중증도에 따른 혈중 Ghrelin 농도 변화

유태우, Yong Kyun Cho, Mun Su Kang, Se Yong Oh, Jung Ho Park, Hong Joo Kim, Dong Il Park, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Chan Hee Jung, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sun Woo Kim, Eun Joo Yun, Eun Sook Oh

Abstract

Background : Recently, ghrelin has been reported to be associated with insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is a condition in which insulin resistance relatively plays a pivotal role. The aim of this study was to evaluate the change of serum ghrelin concentration according to severity of hepatosteatosis.
Methods
: Sixty five apparently normal male adults who underwent health screen examinations were classified into three groups, Group I: normal (27 subjects), Group II: mild (24 subjects) and Group III: moderate to severe fatty liver (14 subjects), according to ultrasonographic findings of liver. We analyzed the association between serum ghrelin concentration and severity of epatosteatosis by ANOVA test. And the independent correlation between serum ghrelin concentration and insulin resistance related factors, HOMA (homeostatic model assessment), BMI (body mass index), WC (waist circumference), HC (hip circumference), WHR (waist to hip circumference ratio) were analyzed by multiple linear regression analysis.
Results
: Serum ghrelin concentration tended to decrease according to severity of hepatosteatosis (Group I: 230.9¡¾94.3, Group II: 195.2¡¾97.2, Group III: 164.3¡¾71.4 pmol/L). But this was statistically insignificant (p=0.081). The independent correlation between serum ghrelin concentration and insulin resistance related factors were not observed.