| Case Reports : A case of Stevens-Johnson syndrome caused by oxcarbazepine |
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Dong Ryeol Ryu, Pil Sang Song, Jin Young Lee, Ji Young Rhee, Mi Jung Oh, Byung Jae Lee, Dong Chull Choi |
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한림의대 한강성심병원 내과 |
| 증례 : Oxcarbazepine 투여 후 발생한 스티븐스 존슨 증후군 1예 |
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류동열, Pil Sang Song, Jin Young Lee, Ji Young Rhee, Mi Jung Oh, Byung Jae Lee, Dong Chull Choi |
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| Abstract |
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Stevens-Johnson syndrome and toxic epidermal necrolysis are acute life-threatening conditions. Aromatic antiepileptic drugs such as carbamazepine, phenytoin and phenobarbital are frequently associated with severe adverse cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis. Oxcarbazepine, a 10-keto derivative of carbamazepine has been reported to have a similar range of efficacy and fewer side effects than carbamazepine because it is a prodrug of a monohydroxy derivative. Because there are few clinical records of oxcarbazepine induced erythemamultiforme-like skin eruptsions, we reported a case of Stevens-Johnson syndrome thought to be caused by the use of oxcarbazepine in a 66-year-old male. Diffuse erythematous maculopapular eruptions were developed on his whole body 30 days after beginning with oxcarbazepine. The clinical and histologic findings of the patient were compatible with Stevens-Johnson syndrome. Although it is rare, oxcarbazepine can cause severe adverse cutaneous reactions.(Korean J Med 70:586-590, 2006)
Key Words : Oxcarbazepine, Stevens-Johnson syndrome |
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