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The Korean Journal of Medicine 2006;70(5): 495-504.
원저 : Non-O157 장출혈성대장균 불현성 감염증 집단유행
박성훈, Sun Hee Kim, Jin Jong Seo, Hye Young Kee, Min Ji Kim, Kye Won Seo, Dong Han Lee, Yeun Hwa Choi, Dong Jin Lim, Young Joo Hur, Seung Hak Cho, Bok Kwon Lee
Original Articles : A phase II study of etoposide (VP-16), ifosfamide, and carboplatin combination chemotherapy plus concurrent thoracic irradiation for limited stage small cell lung cancer
Sunghoon Park, Sun Hee Kim, Jin Jong Seo, Hye Young Kee, Min Ji Kim, Kye Won Seo, Dong Han Lee, Yeun Hwa Choi, Dong Jin Lim, Young Joo Hur, Seung Hak Cho, Bok Kwon Lee
한림의대 한강성심병원 내과
ABSTRACT
Background : No outbreak of Enterohemorrhagic Escherichia coli (EHEC) infection has occurred as a group in Korea. On July 2004, an outbreak of EHEC infection occurred in an elementary school in Gwangju metropolitan city. Epidemic investigation was undertaken to track the source of infection and the mode of transmission of EHEC. Methods : All students and staffs of the elementary school were interviewed and completed questionnaires. We surveyed their clinical symptoms and the foods that they ate. Microbiologic examinations were also carried out on the above school-related persons and many environmental specimens. We also investigated the facilities of the school, some suppliers of food materials, and other associated institutions. All the EHEC-positive persons were isolated in 5 hospitals and tested everyday for verotoxin until they turned out to be negative twice in succession, and their family week also interviewed and tested for EHEC. Pulsed-field gel electrophoresis (PFGE) was performed to find out the genetic relationship between isolates. Results : Of the 1,643 school-related persons, 77 persons (4.7%) were positive for EHEC. Most of them were asymptomatic. All the isolated strains were non-O157 EHEC. Serotype O91 was the most frequent serotype (68 isolates), and the isolates revealing O91 serotypes showed identical PFGE patterns. The school meal was significantly associated with this outbreak (relative risk=13.29, p=0.00). Conclusions : This is the first EHEC outbreak occurred as a group in Korea, All the isolated strains were non-O157 serotypes and the mode of transmission was most likely by school meal.(Korean J Med 70:495-504, 2006) Key Words : Enterohemorrhagic E coli, Verotoxin, Asymtomatic, Outbreak
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