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Keun Ho Lee, Do Young Kim, Ja Kyung Kim, Hyun Soo Chung, Joon Hyung Kim, Yong Han Paik, Kwan Sik Lee, Kwang Hyub Han, Chae Yoon Chon, Young Myoung Moon, Sang H |
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Department of Internal Medicine, Hanyang University College of Medicine |
| 원저 : 간세포암 치료에서 수술 전 간동맥 화학색전술의 효과 (Original Articles : The effect of preoperative transcatheter hepatic arterial chemoembolization in the treatment of hepatocellular carcinoma) |
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이근호, 김도영, 김자경, 정현수, 김준형, 백용한, 이관식, 한광협, 전재윤, 문영명, 안상훈 |
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| Abstract |
Background : Transcatheter hepatic arterial chemoembolization (TACE) is used for curative or
palliative treatment of hepatocellular carcinoma (HCC). However, it is neither well known how much
TACE induces tumor necrosis histologically, nor whether preoperative TACE has benefit for
resectable HCC. The purpose of this study is to measure the degree of tumor necrosis induced by
one session of TACE and to evaluate the effect of preoperative TACE for resectable HCC.
Methods
: Between January 1999 and January 2004, 20 HCC patients with one session of
preoperative TACE (TACE group) and 36 HCC patients with only preoperative hepatic angiography,
without TACE (angiography group) were enrolled.
Results
: In TACE group, 12 patients had tumor necrosis of 100%, 5 patients having between
80% and 99%, and 3 patients less than 50%. The mean tumor necrosis rate of HCC less than 5 cm
in diameter were 84.7%, while 90.5% in larger size (>5 cm in diameter) of HCC (p>0.05). The mean
tumor necrosis rate of the recurred patients in TACE group and in angiography group was 98.75 and
17.5% (p=0.02), respectively. Disease free survival time of the recurred patients in TACE and in
angiography group was 16.75 and 20.25 months, respectively (p=0.77).
Conclusions
: The tumor size was not related with the degree of tumor necrosis and no relevant
factors could be found. Although the mean tumor necrosis was greater in TACE group than in
angiography group, the disease free survival time was not different between the two groups.(Korean
J Med 70:17-25, 2006)
Key Words : Carcinoma, Chemoembolization, Therapeutic |
| Key Words:
Carcinoma, Chemoembolization, Therapeutic |
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