| A case of mesangial proliferative glomerulonephritis associated with ploycytemia vera |
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Cheul Hee Park, Nak So Chung, Woo Kyung Chung, Soo-Mee Bang, Jong Ho Lee, Jaegul Chung, Joon Seung Lee |
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Department of Medicine, Sungkyunkwan University School of Medicine |
| 증례 : 진성다혈구증에 병발된 사구체간질 증식성 사구체 신염 1예 |
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박철희&#;정낙소&#;정우경&#;방수미&#;이종호&#;정재걸&#;이준승, Nak So Chung, Woo Kyung Chung, Soo-Mee Bang, Jong Ho Lee, Jaegul Chung, Joon Seung Lee |
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| Abstract |
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There are only a few reports of glomerulonephritis associated with polycythemia vera (PV). These cases include diffuse mesangial proliferative glomerulonephritis (mesPGN), Henoch-Schӧnlein purpura nephritis, focal segmental glomerulonephritis and IgA nephropathy. In 1983, Plomley et al. reported on 3 cases of mesPGN in patients with PV for the first time. However the possibility that these cases were IgA nephropathy could not be excluded since there was no data of electron microscopic or immnunofluorescent (IF) study. We report a case of idiopathic mesPGN combined with PV. A 46-year-old male was referred to our hospital because of proteinuria and splenomegaly on his routine medical examination. While undergoing investigation for the proteinuria, the patient was found to have a high hemoglobin (22.3 g/dL) and hematocrit (68.8%) levels. At that time, the urinary protein excretion was 3.0 g in 24 hour. We diagnosed the patient as a case of PV by World Health Organization criteria. The renal biopsy revealed focal mesangial proliferation with expansion of the matrix. On IF study, there was no deposition of IgA, IgG and C3 in the mesangium.(Korean J Med 69:S884-S889, 2005) |
| Key Words:
Glomerulonephritis, Polycythemia vera |
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