Association between Serum Fibroblast Growth Factor-21 Levels and Nonalcoholic Fatty Liver in Korean Men with Type 2 Diabetes |
Yong Jae Han, Ji Hye Huh, Jae Ho Seong, Jung Soo Lim, Mi Young Lee, Choon Hee Chung, Jang Yel Shin |
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea |
한국 제2형 당뇨병 남성에서 FGF-21과 비알코올성 지방간의 연관성 |
한용재, 허지혜, 성재호, 임정수, 이미영, 정춘희, 신장열 |
연세대학교 원주의과대학 내과학교실 |
Correspondence:
Jang Yel Shin, Tel: +82-33-741-0509, Fax: +82-33-731-5884, Email: sjy3290@yonsei.ac.kr |
Received: 21 May 2014 • Revised: 18 August 2014 • Accepted: 22 September 2014 |
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Abstract |
Background/Aims Serum fibroblast growth factor-21 (FGF-21) levels are elevated in obesity, metabolic syndrome, and type 2 diabetes. Clinical studies have demonstrated an association between FGF-21 and nonalcoholic fatty liver (NAFL) in the general population. This study investigated the association between FGF-21 and NAFL in Korean men with type 2 diabetes.
Methods Clinical and biochemical metabolic parameters were measured in 135 Korean men with type 2 diabetes (mean age: 56.2 ± 9.2 years; HbA1C: 7.6 ± 1.5%). Serum FGF-21 was determined by enzyme-linked immunosorbent assay. NAFL severity was assessed by ultrasound of the liver. High-grade (hg) NAFL was defined as moderate or severe fatty liver.
Results The patients were divided into three subgroups according to NAFL severity: normal (17.0%), low-grade (50.4%), and high-grade (32.6%). Patients with hgNAFL had a larger waist circumference and higher body mass index (BMI), homeostatic model assessment-estimated insulin resistance (HOMA-IR) score, and triglyceride (TG), liver enzyme, and FGF-21 levels than those with a normal liver. FGF-21 correlated positively with BMI, serum creatinine (Cr), TG, liver enzymes, and high-sensitivity C-reactive protein, but negatively with high density lipoprotein (HDL). In multivariate regression analysis, Cr and TG were independently associated with FGF-21. BMI, TG, HDL, HOMA-IR, and FGF-21 correlated strongly with hgNAFL. The odds ratio (OR) of a 1-standard-deviation increase in FGF-21 predicting hgNAFL was 2.39 (95% confidence interval, 1.55–3.68). The OR remained significant after adjustment for Cr, TG, BMI, and HOMA-IR.
Conclusions Our findings suggest an independent association of serum FGF-21 with NAFL in Korean men with type 2 diabetes. |
Key Words:
Fibroblast growth factor 21; Fatty liver; Diabetes |
주제어:
Fibroblast growth factor-21; 지방간; 당뇨병 |
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