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Korean J Med > Volume 87(1); 2014 > Article
The Korean Journal of Medicine 2014;87(1): 105-109.
항생제 치료로 유발된 혈액응고 제V인자에 대한 후천적 억제인자
임두호1, 김태오1, 정유문1, 김원장1, 박승정1, 이제환1, 장성수2
1울산대학교 의과대학 서울아산병원 내과
2울산대학교 의과대학 서울아산병원 진단검사의학과
Antibiotic-Induced Acquired Factor V Inhibitor
Doo-Ho Lim1, Tae-Oh Kim1, Yumun Jeong1, Won-Jang Kim1, Seung-Jung Park1, Je-Hwan Lee1, Sung-Soo Jang2
1Departments of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Departments of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Corresponding Author: Je-Hwan Lee ,Tel: +82-2-3010-3218, Fax: +82-2-3010-6885, Email: jhlee3@amc.seoul.kr
Received: August 21, 2013;   Revised: October 2, 2013;   Accepted: October 4, 2013.
ABSTRACT
Acquired factor V inhibitor is a rare condition with a variety of clinical manifestations that range from no bleeding symptoms to life-threatening hemorrhage or thromboembolic events. Treatment is determined by the clinical course and focuses on controlling the hemorrhagic event and decreasing the antibody titer if bleeding symptoms are present. We report herein a case involving a 70-year-old man who developed acquired factor V inhibitor after antibiotic administration (11-day course of ceftriaxone and successive 5-day course of piperacillin-tazobactam) for pneumonia. His condition was characterized by elevated prothrombin and activated partial thromboplastin times without bleeding events. Coagulation factor assays revealed undetectable factor V activity and a factor V inhibitor level of 3.29 Bethesda units. After cessation of the antibiotics, both the prothrombin and activated partial thromboplastin times gradually normalized.
Keywords: Factor V deficiency; Inhibitor; Blood coagulation factor; Factor V; Antibiotics
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