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Korean J Med > Volume 86(6); 2014 > Article
The Korean Journal of Medicine 2014;86(6): 695-697.
과민성장증후군 치료전략: 언제, 어떤 약을 사용할 것인가?
김정환, 성인경
건국대학교 의학전문대학원 소화기내과
Strategy to Manage Irritable Bowel Syndrome in Korea
Jeong Hwan Kim, In-Kyung Sung
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
Corresponding Author: In-Kyung Sung ,Tel: +82-2-2030-6182, Fax: +82-2-2030-8290, Email: 2005005@kuh.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders. It is a multi-factorial disorder due to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, and communication between the gut-brain axis. IBS is traditionally treated with dietary and lifestyle modifications, fiber supplementation, and psychological and pharmacological therapies. Diet therapy including the low FODMAP diet and excluding certain food constituents is often used. Antispasmodics plus stool consistency modifiers to treat the major symptoms and defecation are first-line drug treatments. 5-Hydroxytryptamine (5-HT) receptors in the gastrointestinal tract, particularly 5-HT3 and 5-HT4 receptors are involved not only in modulating gut motility but in visceral sensory pathways. Drugs that act on both receptor classes appear to reduce visceral sensitivity and have inhibitory effects on motor activity in the distal intestine. 5-HT4 agonists may improve constipationpredominant IBS by normalizing bowel habits and thereby reduce abdominal pain. IBS continues to be a therapeutic challenge because of its diverse symptomatology and lack of a single pathophysiological target for drug intervention. (Korean J Med 2014;86:695-697)
Keywords: Irritable bowel syndrome; low FODMAP diet; 5-HT4 agonists
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