A Case of Infective Endocarditis with Cytomegalovirus Infection after Kidney Transplantation

Hong, Moon-Ki; Kim, Do-Hyoung; Kim, Chae-Rim; Hong, Joonhwa; Kim, Mi-Kyung; Kim, Su-Hyun

doi:2014.86.5.627

Korean J Med > Volume 86(5); 2014 > Article

Case Report

The Korean Journal of Medicine 2014;86(5):627-631.
Published online May 1, 2014.
DOI: https://doi.org/10.3904/kjm.2014.86.5.627

A Case of Infective Endocarditis with Cytomegalovirus Infection after Kidney Transplantation

Moon-Ki Hong¹, Do-Hyoung Kim¹, Chae-Rim Kim¹, Joonhwa Hong², Mi-Kyung Kim³, Su-Hyun Kim¹

¹Departments of Internal Medicine, Departments of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea
²Departments of Internal Medicine, Departments of Thoracic and Cardiovascular Surgery, Chung-Ang University College of Medicine, Seoul, Korea
³Departments of Internal Medicine, Departments of Pathology Chung-Ang University College of Medicine, Seoul, Korea

신이식 후 거대세포바이러스 감염을 동반한 감염성 심내막염 1예

홍문기¹, 김도형¹, 김채림¹, 홍준화², 김미경³, 김수현¹

^¹중앙대학교 의과대학 내과학교실
^²중앙대학교 의과대학 흉부외과학교실
^³중앙대학교 의과대학 병리학교실

Correspondence:
Su-Hyun Kim, Tel: +82-2-6299-1440, Fax: +82-2-812-0853, Email: sh76so@cau.ac.kr

Received: 7 June 2013 • Revised: 31 July 2013 • Accepted: 9 September 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Advances in immunosuppressive therapy have increased the survival of kidney transplant recipients, yet suppression of the immune system after transplantation can promote infectious complications. Cytomegalovirus (CMV) infection remains one of the most important complications following kidney transplantation and it is a risk factor for developing superinfections with other organisms. Aspergillus endocarditis is a rare life‐threatening complication in kidney transplantation. Coinfection of CMV and Aspergillus endocarditis is rare worldwide and has not been reported in Korea. We report a case of Aspergillus endocarditis that developed in a patient with CMV infection after kidney transplantation. His clinical condition did not improve despite mitral valve replacement and empirical antibiotic treatment, but he was eventually treated successfully with antifungal agents for 6 weeks. (Korean J Med 2014;86:627-631)

Key Words: Aspergillus; Cytomegalovirus; Endocarditis; Kidney transplantation

주제어: 아스페르길루스; 거대세포바이러스; 감염성 심 내막염; 신장이식